Sixty nine patients with squamous cell carcinoma of the lower gingiva were treated by radiotherapy combined with bleomycin (BLM) or peplomycin (PEP).
The complete response (CR) rates after radiation (30Gy/3wks) combined with BLM (90mg/3wks) or PEP (45mg/3wks) was 59% (41/69). Response rate was assessed at three or four weeks after the completion of irradiation. The control rates of T1, T2 cases was 70% (28/40) and that of T3, T4 cases was 45% (13/29).
Of these with CR after Radiotherapy plus BLM or PEP, 25 patients (T1, T2: 16, T3, T4: 9) were followed without surgery. 16 patients (Ti, T2: 11/16, T3, T4: 5/9) achieved local control at 2 years or more.
However, of 9 patients (T1, T2: 5, T3, T4: 4) who had local recurrence, 3 were salvaged.
Ultimate local control rates of patients with CR after radiotherapy plus BLM or PEP was 88% (14/16) in T1, T2 category.
Five year cause specific survival rates was; stage I: 76%, stage II: 74%, stage III: 43%. Overall survival was 64%.
Two year local control rates was; T1: 100%, T2: 72%, T3: 63%, T4: 46%. Overall local control was 70%.
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