ブタ精巣間質を走査型電子顕微鏡を用いて観察した。ブタ精巣間質は, 間質細胞が密な集塊を形成し, この中に少数の血管およびまれにリンパ管が観察された。間質細胞はほぼ球形を呈し, これらの表面には細胞質突起が顕著に発達していた。また, 間質細胞間には網工状を呈
する膠原線維が介在していた。毛細血管は間質細胞群中に認められ, この周囲には周皮細胞, 膠原線維が認められる筋型の毛細血管であった。リンパ管は基底膜の発達が悪く不連続であり, 基底膜を欠く部分にはリンパ管が認められた。

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Lymphedema is defined as a swelling of the arms or legs induced by an obstruction in lymph fluid circulation or by an abnormality in lymph fluid production. In most patients, lymphedema can be diagnosed from the clinical history and physical examination. The lymphangiogram and lymphangioscintigraphy are also used as additional diagnostic tools. Lymphedema developed from an obstruction of the lymphatic system is called secondary lymphedema. Lymphedema is classified into two categories: primary and secondary, and primary lymphedema is rare and is caused by a defect at birth or a congenital lymph system abnormality. The most frequent complication with lymphedema is cellulites. The protein-rich lymph fluid can be a source of bacteria proliferation leading to cellulites, which is an infection in the subcutaneous layers. But if therapy is started from the onset, the risk of infection in edema patients can be lessened. The primary management of lymphedema consist of conservative treatment called complex decongestive physical therapy: CDP or decongestive lymphatic therapy: DLT. The treatment includes skin care, manual lymph drainage, compression therapy, and exercise with bandage or compression garment. If the conservative management does not produce a sufficient effect or the edema worsens, surgical interventions such as microsurgical lymphaticovenular anastomosis and other techniques may be indicated. In Japan, the health insurance system does not offer enough support for patients with lymphedema. The treatment of lymphedema from the early stage is usually effective, and it is therefore necessary for clinicians to have a working knowledge of lymphedema management.

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