In order to quantitate the increase in urinary β₂-microglobulin after exercise urine samples were taken immediately before and after soccer or judo. The titers of β₂-microglobulin were measured by radioimmunoassay. The results were:
1. Both the acutual and the corrected β₂-microglobulin levels increased significantly after exercise soccer, although not before.
2. The total protein tended to be increased after hard exercise soccer.
3. Urinary β₂-microglobulin levels showed similar tends whether the exercise was soccer or judo.

抄録全体を表示

The zinc appears to play a significant roles in enzymatic activities as well as taste qualities, and it has been given cosiderable attention to the decreased serum zinc concentration patients who has been suffering from changes in taste acuity. There is, however, no report regarding the influence of the zinc concentration related to the denture wearers taste qualities.
This study was undetaken to elucidate the correlation between serum zinc concentration and taste acuity in denture wearers. Total of 66 subjects were selected on 35 male and 31 female, aged 22 to 81 years. Within 66 subjects, 16 male and 18 female were denture wearers on aged 35 to 81 years. Serum zinc levels were made using atomic-absorption flame spectrophotometry, and taste thresholds were tested using electrogustometer on the anterior and posterior part of thetongue and on the soft palate.
The results were as follows:
1. Significant decrease in serum zinc concentration with advancing age were obtained in both male and female subjects (Male: Y=123.1 - 0.4 X, R= -0.67, p < 0.01, Female: Y = 103.5-0.2 X, R= -0.37, p< 0.05, where Y is serum zinc concentration in μg/dl and X is age in years).
2. Significant increase in taste-thresholds in every area with advancing age were obtained in both male and female subjects.
3. Denture wearers showed low value of serum zinc concentration (Male: 90.7 μg/dl, Female: 91.7 μg/dl) compared to young subjects (Male: 110.8 μg/dl, Female: 102.6 μg/dl).
4. Denture weares showed high value of taste thresholds (Anterior part of the tongue: 18.8 dB, Posterior part of the tongue: 15.8 dB, Soft palate: 18.9 dB) compared to young subjects (Anterior part of the tongue: 6.6 dB, Posterior part of the tongue: 7.6 dB, Soft palate: 8.8 dB).

抄録全体を表示

Histopathological and ultrastructural changes due to a zinc low diet were investigated in buccal, palatal and tongue mucosa of male 15 weeks rats of Sprague Dawley.
Experimental rats were fed with zinc low diet (1.3 ppm Zn) for 16 weeks. After 16 weeks, experimental rats were then kept on zinc-sufficient diet (50 ppm Zn) for 4 weeks during recovery experiment.
Results were as follows:
1. Zinc concentrations of serum and submandibular gland were decreased significantly (P<0.01) from 2 to 16 weeks respectively. Hair zinc concentrations did not show any significant changes until 4 weeks. But after 8 weeks, those values were lowered significantly (P<0.01). Those zinc concentrations were increased gradually after recovery experiment.
2. Hyperparakeratosis were consistent findings in buccal mucosa, ventral surface and interpapillary mucosa of tongue. Keratohyaline granules in those areas diminished in both size and number. Tonofilaments and ribosomes were increased in cells of granular layer, but did not associated with those granules closely.
3. Hyperparakeratosis were rarely seen in palatal mucosa and filiform papilla of tongue in the experimental rats. Marked hyperorthokeratosis was seen in filiform papilla, and eosinophilic granules in cells of granular layer were increased in both size and number. These granules were closely associated with tonofibrils.
4. These pathological changes were restored to normal after recovery experiment at 2 weeks.
The present results show that zinc deficiency may impede the process of physiological keratinization of oral mucosa in various degrees. It is suggested that zinc deficiency may have a serious consequence on the oral mucosa in its tolerance.

抄録全体を表示