The majority of the therapeutic agents of the DDS series are those with an aromatic ring attached to 4-aminophenylsulfone and the amino radical in the 4 position is considered important from the standpoint of therapeutic effect. It is known that when the amino on both sides of DDS replaced with the acetyl radical, there is a great difference thrapeu-tically. The toxicity is reduced but at the same time, the effect should also be affected. As 4, 4' diacetaminodiphenylsulfone has been found to be effective against pneumococci and streptococci it can be assumed that it is converted to an effective form in the body. The mechanism of action was therefore investigated.
Deacetylization was first studied by extracting the urine and blood of subjects given the agent with ethyl acetate and subjecting the extract to paper electrochromatography. DDS and monoacetate were proven.
The same procedure was carried out in the DDS administered subject and monoacetate was shown to be present. Similar results were obtained with mouse liver.
The pharmacological actions of DDS, the monoacetate and the diacetate were compared. It was found that the toxicity of the latter two was far weaker than that of DDS. It was also found that DDS paralyzes the peripheral endings of the parasympathetic nerves which accelerate intestinal motility, causes a rise in blood pressure and stops the pulsation of the toad heart in systole in a dose of 20*50mg/20cc whereas the latter two agents do not have these actions. On the basis of these results, it was decided that 4, 4'-diacetaminodi-phenylsulfone could be safely used clinically and it was applied in 10 cases of leprosy. It was found that this agent was effective. It is suggested that 4, 4'-diacetaminodiphenyl-sulfone will be useful in cases in which DDS or Promin cannot be to related or in those in which there is no longer any response to Promin or DDS.

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This study aims at clarifying the changes in facility planning for Hansen's disease sanatoriums under the Leprosy Prevention Law based on a review of the literature. The results are as follows:
1) In the late 1940s, the national sanatoriums were planned to accommodate all Hansen's disease patients despite of the unnecessary isolation, as the result of developing effective therapeutic agents. The residents submitted a petition to the authorities to establish the Leprosy Research Center etc.
2) The nationwide organization of the residents negotiated improving the medical service and living environment, preparation for aging, income growth and so on, with the government..
3) In the fourth stage, the nationwide organization prioritized the serious cases by improving their living environment.
4) In the fifth stage, under the limited budgeting resources, an individual facility planning was implemented rather than standardized planning.

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本研究は戦前、日本に唯一存在したハンセン病患者の自由療養地である群馬県吾妻郡草津町湯の沢部落の社会科学的分析の中から、何がハンセン病患者の隔離の二つの側面である「迫害されている患者の社会の圧力からの保護」と「感染源である患者からの社会の防衛」のダイナミズムを後者への優位に導いていったのかを明らかにすることを目的とするものである。その過程は湯の沢部落の実態の解明(「草津湯の沢ハンセン病自由療養地の研究I、II」)、自由療養地議論の展開と消滅の過程の検証と湯の沢部落の関わり(「草津湯の沢ハンセン病自由療養地の研究III」)、湯の沢部落消滅後にその精神が日本の隔離政策に与えた影響(「草津湯の沢ハンセン病自由療養地の研究IV」)などの研究の総体である。
本稿では戦後、栗生楽泉園から始まる患者運動を通して、湯の沢で培われた精神は楽泉園内でも生き続け、患者運動の戦端を開き、「特別病室」を廃止、職員の不正を暴き、やがて多磨全生園と共闘し、「全国癩療養所患者協議会」を生み、絶対隔離政策と対峙する力を形成する様相を描いた。併せて、「特別病室」設置の背景、戦中を中心としての療養所内の混乱の様相とその要因を述べた。

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