Following treatment of precancerous lesions such as dysplasia recurrence and/or carcinoma may develop. The current study presents data to elucidate factors occurring in malignant change through an investigation of the interrelationship between dysplasia and squamous cell carcinoma. The ras p21, c-myc and EGF-R proteins which are produced by each oncogene implicated in dysplasia (ras, myc and erb-B) were immunohistochemically identified from human specimens (38 with dysplasia, 51 with carcinoma, and 20 normal laryngeal epithelium) with the Abidin-Biotin-Peroxidase complex staining method. Results obtained are summarized below :
1. A high positive rate of straining in dysplasia, particularly in histologically high grade specimens, occurred at nearly the same positive rate as in well and moderately differentiated squamous cell carcinoma. The data indicate that positive staining of ras p21, in particular, can serve as a signal of the occurrence of malignant change.
2. The c-myc protein was not found in dysplasia. Even in carcinoma specimens, it was only found in the cancer cell nuclei. This was interpreted to mean that the myc oncogene was related to cell malignancy.
3. The EGF-R in dysplasia was found in the atypical cell. These results suggest that EGF-R expression may be one factor indicating malignant change.
The authors conclude that while the significance of malignant change in dysplasia was not directly assessed in this study, that the study presents sufficient data to warrant further research in this area.
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