The antigenic material (0-antigen) of E. coli O-111 was isolated in a relatively pure condition by the modified method of diethyleneglycol extraction described by Morgan (1940), and by ultracentrifugation (SPINCO).
This study was undertaken to investigate the biological toxicity, especially, pathogenic effects on the intestine of mice and erythrocyte sensitizing activity of this purified antigen. On lesions in the intestine of mice produced by this antigen, the following experiments were carried out. This antigen was decomposed by etherethanol and acetic acid to determine which fraction produces the lesions in the intestine of mice. And these decomposed products were tested in mice to determine whether the products possess harmful action on the intestine of mice or not. Next, the effects of chlorpromazine, tetraethylammonium bromide, prednisolone acetate and hexamethylene-1: 6bistrimethyl-ammonium bromide on this injurious action were observed in order to gain an insight of the mechanism responsible for the lesions.
Furthermore, the physical nature of this antigen were investigated.
The results were as follows:
1) LD₅₀ of this purified 0-antigen prepared from E. coli O-111 was 25.0 mg per kg for mice of the ddN strain and 31.5 mg per kg for mice of the SM strain. By the injection of this antigen into mice, it caused a relatively localized lesion in the intestine. Erythrocytes are sensitized by this antigen, in different ways according

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ヒト慢性関節リウマチの病像モデルとしてラットのアジュバント関節炎を用い, KH-125のステロイド代替治療および併用効果を検討した.1) ステロイド(dexamethasone)の離脱を行ったラットでは反跳(rebound)がみられ, 急速に関節炎が惹起されたが, KH-125で代替治療を行ったラットでは, 反跳はほとんど出現しなかった.2) KH-125とステロイドを併用投与することにより, アジュバント関節炎の発症は抑制された.KH-125の100mg/kgとステロイドの0.02mg/kgは, ステロイドの0.06mg/kg単独群の抑制効果と同等であった.

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The following three characteristics have been ascertained regarding the naishi-dokoro following the Onin War (the Late Muromachi period): 1) The grounds of the naishi-dokoro became open to the public as a festival site; 2) On the occasion of the Tensho period reconstruction, the means for the Naishidokoro's construction and reconstruction were unified; 3) Imperial servants, especially palace guards, came to pay visits to the naishi-dokoro regularly. From these findings, it is argued that the naishi-dokoro dramatically changed in terms of fundamental religious spatial character following the Onin War.

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In recent years, there has been extensive publication of reprints of historical records pertaining to Modern-Period temples. They are published in various forms, such as as supplementary materials for the official history of local communities and reports of the study of old manuscripts carried out by groups of citizens and scholars. This paper proposes an investigation of how to utilize these book-format historical materials with such titles as ‘daily record’ and ‘diary.’ As is well known, previous studies have limited their scope either to one Buddhist sect or one temple. And although the shortcomings of such a practice have been pointed out, there do not seem to be any deviations from this practice. It should be made clear that these materials contain not only the records of annual events and private life but also those of an official nature pertaining to the Government, Imperial Court and Head Temple. As such, it is proposed that they may be used to provide a synchronic record of Modern Period Japanese history.

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This article examines the backdrop against which Toyotomi Hideyoshi was deified with the title of Toyokuni Daimyojin instead of Shin-Hachiman, the title he himself specified in his last will and testament. Despite the fact that who actually promoted deification has by no means been made clear, the author argues that it is necessary to keep in mind that deification was a policy implemented in the midst of the unstable political situation that characterized post-Hideyoshi Japan, and therefore any discussion over who promoted that policy should proceed from an appraisal of the actual situation at that particular time. As a result of the examination of new historical sources clarifying the meaning of the title of Daimyojin and the Toyokuni Shrine and helping to identify those who were involved in their creation within the context of the contemporary political situation, the author has reached the following four conclusions: 1) The title of Daimyojin, which conflicted with Hideyoshi's own wishes, was instituted between the 5th day of the 3rd month and the 10th day of the 4th month of the 4th year of the Keicho Era (1599) under the auspices of Emperor Goyozei, Tokugawa Ieyasu and the vassals of the Toyotomi Clan. 2) Regarding the creation of a brand new title contrary to the wishes of its recipient by emphasizing the idea of Japan as "Toyokuni" (land of prosperity), the consent of Tokugawa Ieyasu was obtained amidst the political chaos arising from the sudden death of the country's supreme commander from ill health during the expeditionary campaigns being waged in Korea and for the purpose of maintaining the centrifugal character of the Toyotomi regime and stabilizing every possible political situation. Consequently, for Ieyasu deification was intended to not only deeply honor the fallen leader, but also to make a clear political statement that Japan had never nor would ever be defeated and conquered by the likes of the Ming Dynasty. 3) In addition, there is the distinct possibility that Ieyasu initially considered between the time just before Hideyoshi's death and the 7th month of Keicho 4 (1599) changing the name Toyotomi to Minamoto. 4) Viewing the situation from Ieyasu's personal political standpoint, the deification of Hideyoshi with the title of Shin-Hachiman would have meant linking him to the genealogy of the patron deity of the Minamoto Clan; however, concluding that Hideyoshi even after his death should be recognized as a Toyotomi as he lived, Ieyasu decided to abandon the initial plan, ignore Hideyoshi's wishes and newly establish the title Toyokuni Daimyojin.

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