Effects of energy restriction diet on heterozygous familial hypercholesterolemia were studied. The choline esterase activity was well correlated with T. cholesterol, and also correlated with intake calory. During intake energy restriction (24Kcal/Kg/day), serum T, cholesterol levels lowered by 43 and 76mg/dl at 4 weeks and 8 weeks respectively. Choline esterase was also decreased. The responders for intake energy restriction could be defined from initial choline esterase activities and the expected cholesterol level controlled by energy restriction was obtained as follow; T, chol. -50×(Ch. E-6). Isocaloric low fat diet (P:F:C=30:15:65) for 2 weeks lowered T, cholesterol by 10%.
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