Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by pruritic and eczematous skin lesions and dermatitis that worsens under stressful conditions. However, the relation of these symptoms to an individual's stress sensitivity is not well understood. On the other hand, expression of the translocator protein (18 kDa) (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been used as a biological marker of trait anxiety and stress sensitivity. The present study was designed to address this issue by examining TSPO in patients with AD. Fifty-two patients with AD (30 male and 22 female) and 163 healthy volunteers (89 male and 74 female) participated in this study. State-Trait Anxiety Inventory (STAI) scores were significantly higher in patients with AD, especially male patients, than in healthy subjects. The expression of platelet TSPO, as determined with a binding assay with [³H] PK11195, was also significantly higher in patients with AD, indicating that AD is a stress-responsive disease. In genomic analysis using lymphocytes, a single-nucleotide polymorphism of the human TSPO gene at exon 4 (485G>A), which is presumably associated with an individual's stress sensitivity, showed significantly lower frequencies of G/G and higher frequencies of G/A in patients with AD than in healthy subjects. The severity of AD, as determined with the Scoring of Atopic Dermatitis index, was correlated with TSPO expression in male patients with the G/A phenotype. In conclusion, the present study provides new evidence that variation in the TSPO gene affects susceptibility to AD.

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日本をとりまく海には約40種の海棲哺乳類が棲息している。彼らをよりよく理解するためにはあらゆる機会を活かし十分な調査を行わなければならない。日本の海岸には年間100件をこす海棲哺乳類のストランディングが報告され, かれらに触れる機会となっている。生死を問わずストランディング個体は限りない情報を我々に提供してくれようとしているのであって, 我々はこれを活用すべく体制をととのえておく必要がある。生存個体の介護, 死亡個体の病理検索など獣医師に期待される部分はきわめて大きい。

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The purpose of this study is to investigate the vertical dynamic charasteristics of two sorts of hybrid wooden floors. The wooden floor is a 6.5m-long-span and 1.0m-wide and consisted of two 120mm wide and 300mm deep laminated wood timbers with 21mm-thick plywood sub-floor. The hybrid concrete-wooden floor has 60mm-thick concrete slab connected by lagscrews onto the wooden floor and the hybrid ALC(Autocraved Lightweight Concrete)-wooden floor has ALC pannels fastened by wood screws onto the wooden floor. The test results indicate, i) The measured first natural frequencies of hybrid wooden floors coincide with those calculated according to the vibration theory for bending continuous model with the bending stiffness and the weight (the sum of dead-load and furniture-load except the human-load) of the hybrid wooden floor, ii) As the rigidity of the joint of concrete and the wooden floor is small, the frictional force between concrete and the wooden floor is not negligible in the bending stiffness, but hardly gives influence on the damping factor, iii) The damping factor at first natural frequency increases in proportion to the rate of human-load over the weight of the hybrid wooden floor.

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