1. Purpose and methods of study.
In order to explain various questions on pathogenesis of hepatitis arising from clinical observation, I took the method which might be called clinical and pathological morphology, that is, the study from the standpoint of our clinical pathological morphology through the dynamic eyes of a clinician.
(N. B.) Study of clinical morphology includes (fine and small vessels of body's sburface, its observation on living body and its piecs of skin for test, organizations taken out in operation, liverbiobsy etc.) Study of pathological morphogy (dissectional study)
2. Classified materials for study. 253 INSTANCES OF LIVER AND SPLEEN DISEASES centering around epidemic hepatitis and 499 instances of contrasts regarding liver and spleen disease.(on human body)
(1) Study centering around the system of fine and small vesses of body's surface.
(a) Study on tissues of vascular-spiders and observation on vascular spiders on a living body. (clinical study on a human body. 195 instances.)
(b) Observation on small vessels of finger nails of a living body. (clinical stlidy on a human body. 23 instances)
(2) Study on internal organtions.
(c) Organ of reticuloendothelial system (liver, spleen, marrow, and limph gland.) 13 instances, of disection of human body.
(d) Other internal organizations. 13 instances of dissection of human body.
(e) Liver and other organizationsin operation, small parts for test and organizations taken out. (clinical study c43 instances)
(f) Liver biobsy. (clinical study c70 instances)
(g) Experiment on liver troubles with allylformiat12 instances of animal experiment. (dog)
(h) Spleen taken out by surgical operation. (so-called Banti's spleen.) 13 instances on clinical study of human body, (Contrast; 13 instances on instances of disection of human body.)
(3) Result and conclusion of study.
(1) Universal significance of small vessels between of body surface and internal organisations affected by epidemic hepatitis, Spleen of Banti's disease and liver cirrhosis.
Conclusion 4. Amendment and development for H. Eppinger's theory on the permeability of small vessels
various morphes of permeability on affected small vessels by epidemic hepatitis and katar jaundice.
a. Troubles of blood fluid (become slow, stop, arterial and venous Hyperemia)
b. Transudation into Disse's tubes and room between tissues and tissues.
c. Capillar walls separated from parenchymal cells, serous fluid around them, blooding, change of wall on small vessels. (resolusion, serperation, swelling, become thick of collagenous, rethieuloendothelial and elastic fibers in liver, etc.)
d. Change of parenchymal substance (various changes of protoplasma nucleous in cells) Cellular reaction, Reparation e. So called Eppinger's II and III type of Katar Jaundice
our
1. Type: (Eppingers's II Type)
2. Type: (Eppingers's II and III type)
3.-1 Type: (Eppingers's III type)
3.-2 Type: (Eppingers'sIII type) (I) Originally it is the genesis of hepatitis in extension that patients suffering from B type hepatitis of inflamation of Glisson's capsule will be taken by a fixed inflamation of Glisson's capsule will be taken by a fixed inflamation of Glisson's capsule for along time since its incipient stage. Hepatitis inflamation will ont only stay within the liver lobule, but affect Glisson's capsule. Therefore, the study must be traced back to Glisson's capsule when we want to know the basic genesis of inflamation of the liver, and so the complete cure for hepatitis can not be expected-if we only stick to the study of the external virus of hepatitis. As it is still difficult for us to study and understand the external virus of hepatitis today, clinicians must give attention to removal of internal troubles in mesenchymalelements as far as the pathology of hepatic have explained concerned.

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