The isolation of 10 sorts of alkaloid, shown in Table I, extracted from Engosan, Chinese plant are described. Two new phenolic bases isolated in protoberberine series alkaloid among them have been named Corydalmine (V) (m.p. 238-239°(vac), [α]
D30+337.4 (CHCl
3), C
20H
23O
4N, colorless needles) and dehydrocorydalmine (VII) (Iodide, m.p. 228-230° (docomp) C
20H
20O
4NI⋅2.5H
2O, yellowish orange needles), respectively. It has been confirmed that O-CH
3 derivative of (VII) corresponded palmatine and that the tetrahydro derivative to (V). The compound (V) provides one hydroxyl group and 3 methoxy groups which may attach at 2, 3, 9 and 10 position.
From the nature of negative reaction to the Gibbs reagents, no hydroxyl group at 3 or 9 position of the tetrahydroberberine nuclei has been found to exist. Furthermore, an admixture of the samples and a comparison with IR spectrum showed that they were not coincidend with tetrahydrojatrorrhizine (II), tetrahydrocolumbamine (III) or palmatrubine (IV). This fact suggested the presence of hydroxy group at 10 and the OCH
3 at 2, 3 and 9. (VII) is the dehydroform of (V).
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