The stability of
Δ9
-tetrahydrocannabinol acetate (
Δ9
-THC-OAc) in the presence of diluents or during vaping was investigated. Laboratory-made pure
Δ9
-THC-OAc and glycerol, propylene glycol (PG), or polyethylene glycol 400 (PEG400) were dissolved in ethanol and subjected to the quantification method for
Δ9
-tetrahydrocannabinol (
Δ9
-THC) recommended by UNODC. The pure
Δ9
-THC-OAc diluted by glycerol, PG, or PEG400 was stored at 40°C for 27 days. A retail liquid product of
Δ9
-THC-OAc containing
Δ9
-THC as an impurity was stored at
80
°C for 28 days in the presence of glycerol, PG, or PEG400. A cartridge containing the
Δ9
-THC-OAc liquid was installed in an
e
-cigarette device, which was heated and vaporized using a syringe connected to the cartridge through a silicone tube. The
Δ9
-THC-OAc liquid was put into a test tube and heated at 200 or 400°C for
5
min. The relative concentrations of cannabinoids in the test solution before and after each operation were measured by liquid chromatography with photodiode array detection or by gas chromatography with flame ionization detection.
Δ9
-THC was not detected in any cases of pure
Δ9
-THC-OAc, and it decreased or disappeared in all cases of
Δ9
-THC-OAc liquid. The present result showed that
Δ9
-THC-OAc does not decompose into
Δ9
-THC during each process.
抄録全体を表示