Cytotoxic Alkaloids of Pachysandra terminalis

Shinji FUNAYAMA; Toshiro NOSHITA; Kazuto SHINODA; Naomi HAGA; Shigeo NOZOE; Masahiko HAYASHI; Kanki KOMIYAMA

doi:10.1248/bpb.23.262

Shinji FUNAYAMA, Toshiro NOSHITA, Kazuto SHINODA, Naomi HAGA, Shigeo NOZOE, Masahiko HAYASHI, Kanki KOMIYAMA

Author information

Keywords: Pachysandra terminalis, Buxaceae, cytotoxic steroidal alkaloid, P388/ADR, pachysamine E, epipachysamine E

JOURNAL FREE ACCESS

2000 Volume 23 Issue 2 Pages 262-264

DOI https://doi.org/10.1248/bpb.23.262

Details

Abstract

Four steroidal alkaloids, epipachysamines B (1) and E (2), pachystermine A (3) and pachysamine E (4), were isolated as cytotoxic principles from the MeOH extract of the stems of Pachysandra terminalis SIEB. et ZUCC. (Buxaceae). These alkaloids showed cytotoxic activity against P388 and P388/ADR leukemia cells in vitro. Three of the alkaloids (1-3) were previously isolated from this plant material, and this is the first report of their cytotoxic activity. Pachysamine E (4) is a new alkaloid.

Corresponding author

Register with J-STAGE for free!