Effect of Ischemic Preconditioning and Mitochondrial KATP Channel Openers on Chronic Left Ventricular Remodeling in the Ischemic-Reperfused Rat Heart

Yuka Dairaku; Toshiro Miura; Nozomu Harada; Masayasu Kimura; Takayuki Okamura; Hiroshi Iwamoto; Ryosuke Kametani; Michio Yamada; Yasuhiro Ikeda; Mitsuo Iwatate; Shuji Kawamura; Masunori Matsuzaki

doi:10.1253/circj.66.411

Experimental Investigation

Effect of Ischemic Preconditioning and Mitochondrial K_ATP Channel Openers on Chronic Left Ventricular Remodeling in the Ischemic-Reperfused Rat Heart

Yuka Dairaku, Toshiro Miura, Nozomu Harada, Masayasu Kimura, Takayuki Okamura, Hiroshi Iwamoto, Ryosuke Kametani, Michio Yamada, Yasuhiro Ikeda, Mitsuo Iwatate, Shuji Kawamura, Masunori Matsuzaki

Author information

Yuka Dairaku
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Toshiro Miura
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Nozomu Harada
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Masayasu Kimura
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Takayuki Okamura
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Hiroshi Iwamoto
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Ryosuke Kametani
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Michio Yamada
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Yasuhiro Ikeda
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Mitsuo Iwatate
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Shuji Kawamura
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine
Masunori Matsuzaki
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicine

Keywords: Diazoxide, Ischemic preconditioning, Nicorandil, Pressure - volume curve

JOURNAL FREE ACCESS

2002 Volume 66 Issue 4 Pages 411-415

DOI https://doi.org/10.1253/circj.66.411

Details

Abstract

The influence of ischemic preconditioning (IP) and mitochondrial _ATP-sensitive potassium (mito-K_ATP) channel openers on chronic left ventricular (LV) remodeling remains unknown, so the effect of IP and mito-K_ATP channel openers on the LV pressure - volume curve was assessed in rats subjected to 30 min ischemia followed by a 3-week reperfusion. Infarct size was histologically determined at 3 weeks after reperfusion. The LV pressure - volume curve was significantly shifted left by IP, diazoxide and nicorandil compared with the controls. These effects were blocked by the selective mito-K_ATP channel blocker 5-hydroxydecanoate. The LV remodeling and the infarct size at 3 weeks after reperfusion correlated well, indicating that the reduction of LV remodeling in the ischemic - reperfused model was strongly influenced by attenuation of the ischemic injury. LV remodeling in the chronic phase is attenuated by IP and mito-KATP channel openers with concomitant reduction of infarct size. (Circ J 2002; 66: 411 - 415)

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