Hemsleyatine, a Novel C₁₉-Diterpenoid Alkaloid with 8-Amino Group from Aconitum hemsleyanum

Abstract

The new compound hemsleyatine (1) was isolated along with four known C₁₉-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), chasmanine (6), and talatisamine (7) from the roots of Aconitum hemsleyanum PRITZ. Structures were established by spectral analysis, including tow dimeusional (2D) NMR spectroscopy and a chemical method. Hemsleyatine (1) is the first C₁₉-diterpenoid alkaloid bearing the 8-amino group. In addition, the assignments of some ¹³C signals for pseudaconine (3) were revised by comparison with those of hemsleyatine (1).