Improvement in the Anticancer Activity of 6-Mercaptopurine via Combination with Bismuth(III)

Yang Yang; Shuang Zhou; Ruizhuo Ouyang; Yaoqin Yang; Huihong Tao; Kai Feng; Xiaoshen Zhang; Fei Xiong; Ning Guo; Tianyu Zong; Penghui Cao; Yuhao Li; Yuqing Miao

doi:10.1248/cpb.c15-00949

Regular Articles

Improvement in the Anticancer Activity of 6-Mercaptopurine via Combination with Bismuth(III)

Yang Yang, Shuang Zhou, Ruizhuo Ouyang , Yaoqin Yang, Huihong Tao, Kai Feng, Xiaoshen Zhang, Fei Xiong, Ning Guo, Tianyu Zong, Penghui Cao, Yuhao Li, Yuqing Miao

Author information

Yang Yang
University of Shanghai for Science and Technology
Shuang Zhou
Cancer Institute, Tongji University School of Medicine
Ruizhuo Ouyang Corresponding author
University of Shanghai for Science and Technology
Yaoqin Yang
Cancer Institute, Tongji University School of Medicine
Huihong Tao
Cancer Institute, Tongji University School of Medicine
Kai Feng
University of Shanghai for Science and Technology
Xiaoshen Zhang
Cancer Institute, Tongji University School of Medicine
Fei Xiong
University of Shanghai for Science and Technology
Ning Guo
University of Shanghai for Science and Technology
Tianyu Zong
University of Shanghai for Science and Technology
Penghui Cao
University of Shanghai for Science and Technology
Yuhao Li
University of Shanghai for Science and Technology
Yuqing Miao
University of Shanghai for Science and Technology

Keywords: 6-mercaptopurine, bismuth, [Bi(MP)₃(NO₃)₂]NO₃, anticancer, A549 cancer cell

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Supplementary material

2016 Volume 64 Issue 11 Pages 1539-1545

DOI https://doi.org/10.1248/cpb.c15-00949

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Abstract

6-Mercaptopurine (6-MP) is a clinically important antitumor drug and its commercially available form is provided as monohydrate, belonging to biopharmaceuticals classification system (BCS) class II category. The combination of bismuth(III) (Bi(III)) with 6-MP was proved to significantly improve the anticancer activity of 6-MP, leading to the discovery of a new amorphous complex ([Bi(MP)₃(NO₃)₂]NO₃). The prepared [Bi(MP)₃(NO₃)₂]NO₃ was characterized by the matrix assisted laser desorption-ionization time-of-flight (MALDI-TOF)-MS, etc. Noticeably, according to the in vitro evaluations of cytotoxicity, cellular apoptotic, colony formation as well as cell migration, the anticancer activity of amorphous [Bi(MP)₃(NO₃)₂]NO₃ was found to be of high therapeutic effect over 6-MP.

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