Synthesis of Aminoisoquinolines and Related Compounds. II. Syntheses of 6-Amino-1-benzylisoquinolines by the Bischler-Napieralski Reaction

Abstract

The Bischler-Napieralski reaction of the phenethylamides (VIa and VIb) was accelerated by the presence of an ethoxycarbamido group in the 3-position of the benzene ring and the ring-closure occured selectively at the position para to the ethoxycarbamido group to give the corresponding 3, 4-dihydroisoquinolines (VIIa and VIIb) in good yields.