Author's Organization：Research Laboratory, Division of Fermentation and Chemical Products, Kohjin Co., Ltd. Research Laboratory, Division of Fermentation and Chemical Products, Kohjin Co., Ltd. Research Laboratory, Division of Fermentation and Chemical Products, Kohjin Co., Ltd.
Cytidine diphosphate choline (CDP-choline), one of the nucleotide coenzymes having pyrophosphate linkages, was synthesized in a fairly good yield by the direct condensation of cytidine-5'monophosphate (5'-CMP) and choline phosphate (P-choline) by means of thionyl chloride combined with dimethylformamide (Vilsmeier-Haack reagent).
