A New Metabolite of Aminopyrine (Aminophenazone) in Man, 4-Formylaminoantipyrine

Abstract

The metabolism and excretion of aminopyrine in man were examined after oral administration. On the gas chromatogram, the extract from urine showed an unknown peak sometimes which seems to be a new metabolite. This new metabolite was identified as 4-formylaminoantipyrine by gas chromatography-mass spectrometry comparing with the synthesized authentic sample.