Abstract
An automated system for the optimization of experimental conditions was applied to the reaction of carboxylic acid. This system consists of a laboratory robotic system, a spectrophotometer, and a personal computer which are interfaced with each other. The optimum conditions were obtained according to the super modified simplex algorithm. This model reaction involved 3 or 4 parameters, and was optimized after 28 experiments at most. The effects of the initial simplex as well as the feasibility and efficiency of the system are discussed.
