1989 Volume 37 Issue 6 Pages 1595-1599
The hydrolysis of gabexate mesilate (GM) in aqueous solution was found to be accelerated by sodium bisulfite (SBS). The hydrolysis in the presence of SBS was pseudo-first-order and the action of SBS was found to be catalytic. In the pH range of 5.0-7.5, the dominant degration process was considered to be a reaction between gabexate cation (G+) and sulfite ion. The rate constant for the catalytic hydrolysis of G+ with sulfite ion was 502.6 M-1 h-1 at 25°C and μ=0.5. The effects of temperature and concentration of SBS on the hydrolysis were evaluated. From these findings, we produced a nomograph to predict the stability of GM in the parenteral admixture containing SBS as an antioxidant.
