Synthesis of Lanosterol Derivatives with a Functional Group at C-32, Including an Antineoplastic Sterol, 3β-Hydroxylanost-7-en-32-oic Acid

Yoshiko SONODA; Kimiko ICHINOSE; Tomoko YOSHIMURA; Yoshihiro SATO; Takuma SASAKI

doi:10.1248/cpb.39.100

Yoshiko SONODA, Kimiko ICHINOSE, Tomoko YOSHIMURA, Yoshihiro SATO, Takuma SASAKI

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Keywords: antitumor activity, lanosterol derivative, 32-functional group, hypoiodite reaction, cholesterol biosynthesis, inhibitor

JOURNAL FREE ACCESS

1991 Volume 39 Issue 1 Pages 100-103

DOI https://doi.org/10.1248/cpb.39.100

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Abstract

Lanosterol derivatives with a functional group at C-32 have been synthesized from 3β-acetoxylanostan-7α-ol. The key reaction of the synthesis is the hypoiodite reaction of 3β-acetoxylanostan-7α-ol. In vitro antitumor activity testing of the lanosterol derivatives revealed that 3β-hydroxylanost-7-en-32-oic acid has antineoplastic activity.

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