抄録
Loratadine, which blocks the peripheral H1 receptor, is a long-acting antihistamine with minimal sedative effects when given at the recommended dose. This present study was undertaken to evaluate the effectiveness of loratadine in patients with Japanese cedar pollinosis, using the Japan rhino-conjuctivitis quality of life questionnaire (JRQLQ).
The subjects consisted of 189 patients who consulted our hospitals and clinics during the peak pollen exposure season in 2007 (between Feburary 26 and March 10). The patients were divided into two groups; patients who had taken loratadine once daily prior to entering this study were classified as the treated group (n=65), while patients without any previous treatment were classified as the non-treated group (n=124).
The results showed that the nasal symptoms in the treated group were milder than those in the untreated group, and that furthermore, the treated group could maintain a good quality of life.
In years with extensive scattering of Japanese cedar pollen, prophylactic treatment with loratadine is effective, safe and should be considered when choosing a strongly effective drug for prophylactic treatment
