Solitary neurofibroma of the head and neck is rare. A 72-year-old woman presented with a tumor in the mental region. The tumor had a smooth surface, elastic soft consistency, and measured approximately 8×10×10mm. The clinical diagnosis was a benign tumor of the mental region. The mass was excised under local anesthesia. Histologically, the tumor was clearly encapsulated and composed of proliferations of spindle-shape cells with wavy collagen fibers in a myxomatous stroma. Immunohistochemical examination showed some tumor cells stained positively with anti-S-100 protein and anti-neuron specific enolase antibodies. Neither cafe au lait spots nor other neurofibromas were observed on physical examination. This case was finally diagnosed as a solitary neurofibroma of the middle part of the mental region.
