1972 Volume 36 Issue 2 Pages 227-233
The accumulation of 5'-IMP or 5'-XMP by adenine-requiring or adenine-guanine-requiring mutants of Bacillus subtilis with weak 5'-nucleotidase was greatly increased by cultivating them at a high temperature (40°C). The accumulation was markedly increased by addition of hypoxanthine or xanthine to the medium.
It is suggested that in these mutants, 5'-IMP and 5'-XMP are secondarily resynthesized through salvage pathways from their respective bases that have been accumulated first in the medium and these processes are activated at this high temperature.
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