Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection

Hideharu Hagiya; Junzo Hisatsune; Taro Kojima; Sumiko Shiota; Hiromichi Naito; Shingo Hagioka; Naoki Morimoto; Fumio Otsuka; Motoyuki Sugai

doi:10.2169/internalmedicine.53.1746

CASE REPORTS

Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection

Hideharu Hagiya, Junzo Hisatsune, Taro Kojima, Sumiko Shiota, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto, Fumio Otsuka, Motoyuki Sugai

Author information

Hideharu Hagiya
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
Junzo Hisatsune
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan
Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
Taro Kojima
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan
Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
Sumiko Shiota
Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University, Japan
Hiromichi Naito
Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
Shingo Hagioka
Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
Naoki Morimoto
Emergency Unit and Critical Care Center, Tsuyama Central Hospital, Japan
Fumio Otsuka
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Motoyuki Sugai
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Japan
Department of Bacteriology, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan

Keywords: community-acquired methicillin-resistant Staphylococcus aureus, multilocus sequence type 8, sepsis, toxic shock syndrome, USA300

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 8 Pages 907-912

DOI https://doi.org/10.2169/internalmedicine.53.1746

Details

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

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