The relation of rate-corrected mean velocity of fiber shortening (mVcfc)-end-systolic wall stress (ESS) is a load-independent index of left ventricular contractility, but involves simultaneous M-mode echocardiography, carotid or axillary pulse tracing and blood pressure determination, which may be impractical in younger infants. We examined whether the relation of the peak systolic wall stress (PSS)-mVcfc could be used as a simpler method of assessing left ventricular contractility in preterm and fullterm infants. In 45 preterm and fullterm infants, mVcfc, ESS, and PSS were determined using echocardiography, axillary pulse tracing and blood pressure measurement. Five patients with left ventricular dysfunction or low cardiac output state were also studied. The relation of PSS and ESS was PSS=5.19+1.04 ESS (r=0.98, p<0.01). The slope of mVcfc=1.58−0.012 ESS (r=−0.78, p<0.01) was nearly identical to that of mVcfc=1.60−0.011 PSS (r=−0.75, p<0.01), with no difference in the regression coefficients. The relationship of PSS and ESS in 5 patients was very close and the slope of the regression line was nearly identical to that of 45 infants. The relation of mVcfc-PSS correlates well with the relation using ESS and can be used as a simple method of assessing left ventricular contractility.