抄録
The U.S. National Toxicology Program's Interagency Center for the Evaluation of Alternative Methods and its Interagency Coordinating Committee on the Validation of Alternative Methods recently completed and planned several activities to promote the development, validation and regulatory acceptance of alternative methods for regulatory safety testing. Recommendations for new allergic contact dermatitis test methods were accepted in the U.S. and internationally by the OECD. An international workshop developed recommendations to advance alternative methods for human and veterinary vaccine potency and safety testing. Wokshops on best practices for assessing the eye injury and allergic contact dermatitis potential of chemicals and products were convened to foster the use of accepted new test methods. An upcoming international panel will evaluate the validity of an in vitro estrogen receptor transcriptional activation assay. These activities are expected to improve global animal welfare and reduce animal use while ensuring continued protection of people, animals, and the environment.
