Susd2/SUSD2, a putative tumor suppressor gene, inhibits growth of colorectal cancer cells

Toshiwo Andoh; Kensuke Kumamoto; Shinichi Suzuki; Yoshiko Matsumoto; Chiyo Oukouchi; Manabu Iwadate; Satoshi Suzuki; Hiroshi Mizunuma; Seiichi Takenoshita

doi:10.4993/acrt.26.77

Susd2/SUSD2, a putative tumor suppressor gene, inhibits growth of colorectal cancer cells

Toshiwo Andoh, Kensuke Kumamoto, Shinichi Suzuki, Yoshiko Matsumoto, Chiyo Oukouchi, Manabu Iwadate, Satoshi Suzuki, Hiroshi Mizunuma, Seiichi Takenoshita

著者情報

キーワード: Tumor suppressor gene, Susd2/SUSD2, TS

ジャーナルフリー

2018 年 26 巻 2 号 p. 77-81

DOI https://doi.org/10.4993/acrt.26.77

詳細

抄録

We constructed inducible expression system of Susd2 gene which we previously identified as a novel tumor suppressor gene. Here we report the growth inhibition of colorectal cancer HCT116 cells and fibrosarcoma HT1080 cells by inducible expression of Susd2 protein from HCT/G5Susd2 and HT/G5Susd2 cells by infection of Ad/G4VP2, as revealed by colony formation and growth behavior. Thus, we found that Susd2 inhibits growth of cancer cells and this information may benefit to patients with malignant diseases.

責任著者(Corresponding author)

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