1996 年 5 巻 1 号 p. 29-33
Cancer cells must express intercellular adhesion molecule-1 (ICAM-1) to be recognized and killed by lymphocytes. The expression of ICAM-1 by tumor cells was studied in 89 patients with colorectal cancer and the soluble form of this molecule was measured in the systemic and local circulation.
No ICAM-1 expression was observed in normal colonic mucosa and the percentage of tumor specimens positive for ICAM-1 decreased as the disease advanced (Dukes' classification, P<0.01). The percentage of positive tumor specimens was lower among patients with nodal involvement (P<0.05) or lymphatic invasion (P<0.01). The soluble ICAM-1 concentration in the tumor draining vein tended to be higher in patients with a greater number of tumor-infiltrating lymphocytes (P<0.01) and in patients with cancer cells expressing ICAM-1 (P<0.01).
