Recurrent breast carcinoma after prior intensive therapy responsive to biochemical modulation of 5-FU with low-dose cisplatin

Case report

抄録

A 53-year-old woman with breast carcinoma underwent modified radical mastectomy and intensive adjuvant chemoendocrine therapy (including CAF therapy), but developed bone metastasis. After resection of the metastatic focus and further chemoendocrine therapy, she developed multiple bone metastases and pain in the right upper arm. One course of 5-fluorouracil combined with low-dose cisplatin achieved remarkable pain relief and new calcification of the lytic lesion in the humerus. There were no major side effects of this therapy. Unfortunately, spinal cord injury due to vertebral compression fracture forced us to discontinue treatment, so the duration of partial remission was less than two months. However, the response to this modulation regimen in a patient with very intensive prior therapy is notable.