Drug shortages are a complex global problem, therefore, to solve this issue with the drug shortages, all of stakeholders; pharmaceutical companies, hospitals, government and others needed to participate in managing the drug shortages and also, the stakeholders have to quantify and identify the underlying causes and actual impact of the drug shortages. However, there are a few original articles only to show specific solution for the drug shortage. Therefore, this study endeavors to evaluate some issues which are focused on antimicrobial.