光反応を利用した生体機能表面の創出

抄録

In this review articles, the recent studies on photochemical surface immobilization of phospholipidpolymers have been summarized. It is well known that phospholipid polymers can reduce nonspecific proteinadsorption, cell adhesion and foreign body reaction. In order to accomplish universal surface immobilization ofphospholipid polymers, photochemical processes have been recently employed. The processes can be mainlydivided into surface-initiated photopolymerization and immobilization of phospholipid polymers bearingphotoreactive functional groups. The surface-initiated photopolymerization is applicable not only to producingnon-fouling surfaces but also making surfaces lubricant. This process is then used for long-lasting artificialhip joint implants. In contrast, photo-reactive phospholipid polymers are useful for versatile and regiospecificsurface modification of various substrates which can be applied in biomedical fields.