Fabrication of Cyanoacrylate Hollow Particles using Microbubble Generation Technique

抄録

This paper describes the fabrication of hollow particles using microbubble generation technique. Conventional hollow particle generation techniques relate to several problems such as long synthesis time and complicated process. In this study, we succeeded in the fabrication of hollow particles having a diameter of <5 μm by simply blowing cyanoacrylate vapor into water in the form of microbubbles. However, in order to apply the hollow particles for medical applications, it is required to decreasing the diameter. Therefore, in the form of microbubbles and examined the effect of pH and gas supply on the fabricated particles. As a result, hollow particles fabricated in pH 3 condition were much smaller than those fabricated in pH 7 condition, and the use of poorly-soluble gas increased the ratio of hollow particles to solid particles. The CA particles prepared in this study would possibly have excellent thermal and sound insulation properties owing to the hollow structure. Furthermore, though further downsizing of hollow particles are required, CA particles can find the application for drug delivery to the targeted sites.