Application of Genetic Engineering Technologies for the Study of Pituitary Development and Neoplasms

Robert Yoshiyuki Osamura; Shunsuke Miyai; Noboru Egashira; Susumu Takekoshi; Michio Yamazaki; Naoko Sanno; Akira Teramoto

doi:10.1267/ahc.36.249

REVIEW

Application of Genetic Engineering Technologies for the Study of Pituitary Development and Neoplasms

Robert Yoshiyuki Osamura, Shunsuke Miyai, Noboru Egashira, Susumu Takekoshi, Michio Yamazaki, Naoko Sanno, Akira Teramoto

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Keywords: pituitary gland, pituitary adenoma, gene transfection, secretory pathway, transcription factor

JOURNAL FREE ACCESS

2003 Volume 36 Issue 4 Pages 249-254

DOI https://doi.org/10.1267/ahc.36.249

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Abstract

Our studies and review of the literature reported by other investigators indicate the essential use of genetic engineering technology to study the physiologic and pathologic mechanisms of transcription of hormone production and the mechanisms of secretion of appropriate bioactive peptides from the prohormones in the endocrine cells which are equipped with secretory granules.

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