ACTA HISTOCHEMICA ET CYTOCHEMICA
Online ISSN : 1347-5800
Print ISSN : 0044-5991
ISSN-L : 0044-5991
REGULAR ARTICLE
Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT
Hiromi OnizukaKenta MasuiKosaku AmanoTakakazu KawamataTomoko YamamotoYoji NagashimaNoriyuki Shibata
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2021 Volume 54 Issue 3 Pages 87-96

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Abstract

Pituitary adenomas are common, benign brain tumors. Some tumors show aggressive phenotypes including early recurrence, local invasion and distant metastasis, but the underlying mechanism to drive the progression of pituitary tumors has remained to be clarified. Aerobic glycolysis known as the Warburg effect is one of the emerging hallmarks of cancer, which has an impact on the tumor biology partly through epigenetic regulation of the tumor-promoting genes. Here, we demonstrate metabolic reprogramming in pituitary tumors contributes to tumor cell growth with epigenetic changes such as histone acetylation. Notably, a shift in histone acetylation increases the expression of telomerase reverse transcriptase (TERT) oncogene, which drives metabolism-dependent cell proliferation in pituitary tumors. These indicate that epigenetic changes could be the specific biomarker for predicting the behavior of pituitary tumors and exploitable as a novel target for the aggressive types of the pituitary tumors.

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© 2021 The Japan Society of Histochemistry and Cytochemistry

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https://creativecommons.org/licenses/by-nc/4.0/
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