Abstract
The heptacosapeptide amide corresponding to the entire amino acid sequence of porcine gastrin releasing peptide (GRP), which had been isolated from porcine non-antral and intestinal tissue by McDonald et al. (5) and its amino acid sequence tentatively determined, was synthesized by Yajima et al. (11). Albino rabbits were immunized with this synthesized GRP and specific antiserum was obtained. Using an immunofluorescence antibody technique, cellular localization of GRP in the human stomach was examined.
GRP containing cells were clearly demonstrated in the mucosa of antrum of the stomach of a patient with a duodenal ulcer.
