Abstract
The metalloproteins in the liver of p-dimethylaminoazobenzene (DAB)-treated rats were analyzed by means of immunohistochemical and electron spin resonance (ESR) techniques in comparison with normal or carbon tetrachloride-damaged livers. Immunohistological method revealed intensive distribution of serum ceruloplasmin and transferrin in DAB induced tumor tissues. Concomitantly, a remarkable increase was also noted in the ESR signals of both cupric ion and non-heme ferric ion of rhombic high-spin form, which were ascribed to these metalloproteins. Their biological implications in malignancy are discussed.
