Abstract
Ischaemia in rat soleus muscles induced with a single high dose of 5-hydroxytryptamine caused a loss of activity of alkaline phosphatase, aminopeptidase A and dipeptidyl peptidase IV from capillaries adjacent to and within the most severe muscle lesions. Three days after the insult about 75% activity had returned to the capillaries, and by 6 days normal levels were restored. Loss and recovery of enzyme activity was paralleled by degeneration and regeneration of the muscle fibres.
