Abstract
Protein kinase A (PKA) was localized in the rat hippocampus by an immunohistochemcal technique. The antibody was raised against the catalytic subunit of bovine heart PKA and cross-reacted with the brain enzyme, as could be revealed by immunoblotting. The strongest reaction was detected in the pyramidal and granular cell layers and in the lacunoso-molecular layer of the hippocampus formation. The reaction in the radial layer was restricted to the dendrites of the pyramidal cells. In the other regions mainly filial cells were stained.
