FACTOR XIIIa-POSITIVE CELLS IN THE HUMAN PULMONARY TISSUES: AN IMMUNOHISTOCHEMICAL STUDY

MAKOTO TOIDA; YASUAKI OKUMURA; YUJIRO HANDA; FUMIO WATANABE; NORICHIKA TATEMATSU; NOBUMITSU OKA; TSUYOSHI TAKAMI; AKITSUGU OJIMA

doi:10.1267/ahc.23.671

MAKOTO TOIDA, YASUAKI OKUMURA, YUJIRO HANDA, FUMIO WATANABE, NORICHIKA TATEMATSU, NOBUMITSU OKA, TSUYOSHI TAKAMI, AKITSUGU OJIMA

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MAKOTO TOIDA
Department of Oral Surgery and Oral Medicine, Ibi General Hospital
Department of Pathology Division, Clinical Laboratory, Ibi General Hospital
YASUAKI OKUMURA
Department of Oral and Maxillo-Facial Surgery, Gifu University School of Medicine
YUJIRO HANDA
Department of Oral and Maxillo-Facial Surgery, Gifu University School of Medicine
FUMIO WATANABE
Department of Oral Surgery and Oral Medicine, Ibi General Hospital
NORICHIKA TATEMATSU
Department of Oral and Maxillo-Facial Surgery, Gifu University School of Medicine
NOBUMITSU OKA
Department of Oral and Maxillo-Facial Surgery, Gifu University School of Medicine
TSUYOSHI TAKAMI
Department of Pathology, Gifu University School of Medicine
AKITSUGU OJIMA
Department of Pathology, Gifu University School of Medicine

JOURNAL FREE ACCESS

1990 Volume 23 Issue 5 Pages 671-678

DOI https://doi.org/10.1267/ahc.23.671

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Abstract

The distribution of subunit A of blood coagulation factor XIII (FXIIIa) was investigated in human pulmonary tissues by the avidin-biotin-peroxidase complex (ABC) method. FXIIIa was detected in certain connective tissue cells, including dust-laden cells of the subpleural areas and alveolar septa as well as in alveolar macrophages, but not in type I or type II alveolar epithelial cells. These findings agree well with the widely accepted conception that pulmonary macrophages are part of the general mononuclear phagocyte system (MPS). The biological role of the FXIIIa-positive pulmonary cells is also discussed in this paper.

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