HISTOPATHOLOGICAL AND HISTOCHEMICAL CHANGES IN VARIOUS TYPES OF MUSCULAR DYSTROPHY

Abstract

Morphological and histochemical difference and feature of each type of progressive muscular dystrophy (PMD) of 84 cases were stated. Especially interesting observations were obtained in the progress of lesion of skeletal muscle and in the comparison between Duchenne type and congenital type.
In PMD, lesion of pale muscle precedes and, as the course of the disease progresses, it becomes accompanied by lesion of red muscle. The size of muscle fiber and the strength of PhR activity do not always show abreast change. In limb-girdle type, some case shows singular observation in distribution of PhR and SDH activity.
In benign Duchenne type, carrier of Duchenne type, and ocular PMD, degree of morphological change and lesion in distribution of enzyme activity is low.
In congenital PMD, histological feature similar to the muscle of 6 to 8 months old fetus is observed. Morphological changes of not only muscle fiber but also motor endplate are pretty characteristic.
Regeneration of muscle fiber can be observed most in benign Duchenne type and ocular type.
A few more discussions were made on the feature of boule musculaire and extraocular muscle in addition to the pathohistochemical observations stated above.