An Immunohistochemical Study of the Localization of Biglycan, Decorin and Large Chondroitin-sulphate Proteoglycan in Pleomorphic Adenoma

Yoshihiro Abiko; Michiko Nishimura; Jiro Mitamura; Firoz Rahemtulla; Paul. G. Scott; Carole M. Dodd; Itaru Mizoguchi; Tohru Kaku

doi:10.1267/ahc.32.459

Yoshihiro Abiko, Michiko Nishimura, Jiro Mitamura, Firoz Rahemtulla, Paul. G. Scott, Carole M. Dodd, Itaru Mizoguchi, Tohru Kaku

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Keywords: PG-M/Versican, Biglycan, Salivary gland, Pleomorphic adenoma, Immuno-histochemistry

JOURNAL FREE ACCESS

1999 Volume 32 Issue 6 Pages 459-463

DOI https://doi.org/10.1267/ahc.32.459

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Abstract

The present study investigated the localization of biglycan, decorin and large chon-droitin-sulphate proteoglycans (versican) in 32 cases of pleomorphic adenoma (PA) by immunohistochemical staining. The neo-plastic epithelium of PA showed wide staining for versican and biglycan. Myxomatous and chondroid tissues showed restricted staining for versican and biglycan. The intense staining for decorin was observed in fibrous connective tissue of the capsule, whereas only one case in the present study showed the positive staining for decorin in the mesenchymal tissues of PA. These results indicated that both biglycan and versican might be involved in, at least in part, the morphogenesis of neoplastic epithelium and mesenchymal tissues in PA.

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