In order to clarify the mechanism of indoor air pollution with semi-volatile organic compounds (SVOC), it is important to accurately measure the emission rates from building materials and products. The authors have already reported the thermal desorption test chamber method (TDC method) that can measure the emission rates of SVOC from test pieces of materials with certain accuracy. In this study, we evaluated the reliability and accuracy of the TDC method from the various points of measurement procedures. In these evaluations, it was found that the accuracy of the measurement depends on the configuration, volume, and inertness of the chamber.