In this study, we propose a quantitative evaluation method and criteria for aerosol infection risk. By using the Wells-Riley model, we derived the infection probability and calculated the number of secondary infections in a room considering spatial distribution, thus setting the infection risk assessment value. As a criterion for containing the infection, we adopted the condition that the number of secondary infections should be less than one. The case study showed that floor inlets systems have lower infection risk compared to the ceiling inlets, and the placement of air inlets and outlets has a significant impact on the risk.