The purpose of this paper is to study the effect of a seismic isolation system on the responses of the space frame structures where hysteresis dampers are installed to reduce the responses due to horizontal earthquake motion. This system is applied to a latticed dome with about 300m span, and dynamic response analysis of the system is carried out to illustrate the effectiveness. From the results of the numerical studies with dome, it is confirmed that the seismic isolation system with hysteresis dampers effectively suppress the vertical and horizontal acceleration responses of the dome subjected to horizontal earthquakes.