Lessons learned from the 1995 Hyogoken Nanbu earthquake and the excellent performance of seismically isolated structures during the earthquake have persuaded the application of seismic isolation systems to houses. Because of a light weight of houses sliding and rolling types of isolators have been developed. A purpose of this paper is to verify the behaviors of seismic isolation systems under 3-directional recorded earthquake ground motions. 3-dimensional shaking table tests on full-scale seismic isolation systems with different types of isolators were conducted. In this paper, the effects of earthquake motions with 2-horizontal and vertical components on the response characteristics of the seismic isolation systems are discussed.