Eccentric beam-to-square tubular column connections in steel building frames have been investigated by many researchers. For eccentric beam-to-wide flange column connections, fewer efforts have been made in the past. In a recent study by the authors, local strength of the eccentric beam flange-to-wide flange column connections was examined. This paper presents strength evaluation of panel zones in the eccentric beam-to-wide flange column connections. A torsional moment induced by an eccentric beam-flange force is considered in the derivation of the panel zone strength formula. Cyclic loading tests of T-shaped connection models have been conducted to examine the hysteretic characteristics. The test results show that the eccentric connections have adequate ductility and hysteretic energy dissipation capacity. The strength formula of the panel zones has a reasonable accuracy. Elastic-plastic finite element analyses performed for the cruciform connection models demonstrate influence of the stiffener sizes on the panel zone strength.