This research is concerned with the earthquake response of 3-dimensional multi-story steel moment frames with eccentricity. In this paper, we propose a simplified dynamic model for the frames. The model, which has six degrees of freedom for each story, is used to conduct earthquake response analyses. The results are compared with those from finite element method analysis using ABAQUS. It is clarified that the earthquake response of the frames is approximated through a numerical study using this model.