This paper performed a series of nonlinear response history analyses (NLRHAs) for double-layered domes supported by single-story substructures to investigate the effect of the roof span L of 60m to 150m, yielding story drift ratio θy, yielding base shear coefficient Cy of 0.3 to 0.6, post-yielding stiffness ratio p of 0.01 to 0.5 on the seismic force reduction factor Ds and ductility ratio μ. Furthermore, a simple force reduction factor evaluation method considering the resonance between the dome and substructure was proposed. Finally, static analyses with an equivalent seismic load with the proposed Ds were compared to the NLRHAs.