This paper extended the seismic force reduction factor Ds evaluation method previously proposed by the authors to double-layered domes supported by multistory substructures. The evaluation procedure is carefully formulated based on Japanese Building Code. Furthermore, the extended evaluation method was strictly validated by using a series of nonlinear response history analyses (NLRHAs) of a massive amount of double-layered domes supported by multistory substructures. Finally, static analyses with an equivalent seismic load with the proposed Ds were compared to the NLRHAs.